Generation of high-affinity human antibodies by combining donor-derived and synthetic complementarity-determining-region diversity.

Hoet, René Michael

Generation of high-affinity human antibodies by combining donor-derived and synthetic complementarity-determining-region diversity. [electronic resource] - Nature biotechnology Mar 2005 - 344-8 p. digital

Publication Type: Letter

1087-0156

10.1038/nbt1067 doi


Antibody Affinity
Antibody Formation
Complementarity Determining Regions--genetics
Genetic Variation--genetics
Humans
Immunoglobulin Fab Fragments--biosynthesis
Peptide Library
Protein Binding
Protein Engineering--methods
Recombination, Genetic--genetics
Tissue Donors