Impact of remote mutations on metallo-beta-lactamase substrate specificity: implications for the evolution of antibiotic resistance.

Oelschlaeger, Peter

Impact of remote mutations on metallo-beta-lactamase substrate specificity: implications for the evolution of antibiotic resistance. [electronic resource] - Protein science : a publication of the Protein Society Mar 2005 - 765-74 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0961-8368

10.1110/ps.041093405 doi


Biological Evolution
Drug Design
Drug Resistance, Bacterial--genetics
Escherichia coli--enzymology
Kinetics
Mutation
Substrate Specificity--genetics
beta-Lactamases--genetics