TRAIL-induced apoptosis in gliomas is enhanced by Akt-inhibition and is independent of JNK activation.

Puduvalli, V K

TRAIL-induced apoptosis in gliomas is enhanced by Akt-inhibition and is independent of JNK activation. [electronic resource] - Apoptosis : an international journal on programmed cell death Jan 2005 - 233-43 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.

1360-8185

10.1007/s10495-005-6078-3 doi


Apoptosis
Apoptosis Regulatory Proteins
Cell Line, Tumor
Enzyme Activation
Glioma--pathology
Humans
JNK Mitogen-Activated Protein Kinases--metabolism
MAP Kinase Kinase 4
Membrane Glycoproteins--physiology
Mitogen-Activated Protein Kinase Kinases--metabolism
Protein Serine-Threonine Kinases--antagonists & inhibitors
Proto-Oncogene Proteins--antagonists & inhibitors
Proto-Oncogene Proteins c-akt
Signal Transduction
TNF-Related Apoptosis-Inducing Ligand
Tumor Necrosis Factor-alpha--physiology