PIP2 hydrolysis underlies agonist-induced inhibition and regulates voltage gating of two-pore domain K+ channels.

Lopes, Coeli M B

PIP2 hydrolysis underlies agonist-induced inhibition and regulates voltage gating of two-pore domain K+ channels. [electronic resource] - The Journal of physiology Apr 2005 - 117-29 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

0022-3751

10.1113/jphysiol.2004.081935 doi


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Animals
Female
Humans
Hydrolysis--drug effects
Ion Channel Gating--drug effects
Mice
Phosphatidylinositol 4,5-Diphosphate--metabolism
Polylysine--pharmacology
Potassium Channels, Voltage-Gated--agonists
Protein Structure, Tertiary--physiology
Rats
Wortmannin
Xenopus