Induction of CYP1A1 and CYP1B1 in liver and lung by benzo(a)pyrene and 7,12-d imethylbenz(a)anthracene do not affect distribution of polycyclic hydrocarbons to target tissue: role of AhR and CYP1B1 in bone marrow cytotoxicity.

Galván, Noé

Induction of CYP1A1 and CYP1B1 in liver and lung by benzo(a)pyrene and 7,12-d imethylbenz(a)anthracene do not affect distribution of polycyclic hydrocarbons to target tissue: role of AhR and CYP1B1 in bone marrow cytotoxicity. [electronic resource] - Toxicology and applied pharmacology Feb 2005 - 244-57 p. digital

Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

0041-008X

10.1016/j.taap.2004.06.026 doi


9,10-Dimethyl-1,2-benzanthracene--pharmacokinetics
Animals
Aryl Hydrocarbon Hydroxylases--biosynthesis
Benzo(a)pyrene--pharmacokinetics
Bone Marrow Cells--drug effects
Carcinogens, Environmental--pharmacokinetics
Cells, Cultured
Cytochrome P-450 CYP1A1--biosynthesis
Cytochrome P-450 CYP1B1
DNA Adducts--biosynthesis
Enzyme Induction
In Situ Hybridization
Liver--drug effects
Lung--drug effects
Male
Mice
Mice, Inbred C57BL
Polycyclic Compounds--pharmacokinetics
RNA, Messenger--biosynthesis
Receptors, Aryl Hydrocarbon--physiology
Tissue Distribution