Hypermethylation of the death-associated protein kinase promoter attenuates the sensitivity to TRAIL-induced apoptosis in human non-small cell lung cancer cells.

Tang, Ximing

Hypermethylation of the death-associated protein kinase promoter attenuates the sensitivity to TRAIL-induced apoptosis in human non-small cell lung cancer cells. [electronic resource] - Molecular cancer research : MCR Dec 2004 - 685-91 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.

1541-7786


Antimetabolites, Antineoplastic--pharmacology
Apoptosis
Apoptosis Regulatory Proteins
Azacitidine--analogs & derivatives
Calcium-Calmodulin-Dependent Protein Kinases--biosynthesis
Carcinoma, Non-Small-Cell Lung--genetics
Cell Line, Tumor
Cloning, Molecular
Coloring Agents--pharmacology
DNA Fragmentation
DNA Methylation
DNA, Complementary--metabolism
Death-Associated Protein Kinases
Decitabine
Dose-Response Relationship, Drug
Drug Resistance, Neoplasm
Fas Ligand Protein
Humans
Immunohistochemistry
In Situ Nick-End Labeling
Lung Neoplasms--genetics
Membrane Glycoproteins--metabolism
Polymerase Chain Reaction
Promoter Regions, Genetic
RNA, Messenger--metabolism
Receptors, TNF-Related Apoptosis-Inducing Ligand
Receptors, Tumor Necrosis Factor--metabolism
Reverse Transcriptase Polymerase Chain Reaction
TNF-Related Apoptosis-Inducing Ligand
Tetrazolium Salts--pharmacology
Thiazoles--pharmacology
Time Factors
Treatment Outcome
Tumor Necrosis Factor-alpha--metabolism