High epitope density in a single protein molecule significantly enhances antigenicity as well as immunogenicity: a novel strategy for modern vaccine development and a preliminary investigation about B cell discrimination of monomeric proteins.

Liu, Wanli

High epitope density in a single protein molecule significantly enhances antigenicity as well as immunogenicity: a novel strategy for modern vaccine development and a preliminary investigation about B cell discrimination of monomeric proteins. [electronic resource] - European journal of immunology Feb 2005 - 505-14 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0014-2980

10.1002/eji.200425749 doi


Animals
Antibodies, Monoclonal--immunology
Antigens--immunology
B-Lymphocytes--immunology
Enzyme-Linked Immunosorbent Assay
Epitopes--immunology
Glutathione Transferase--genetics
Kinetics
Orthomyxoviridae--immunology
Protein Binding
Proteins--immunology
Rabbits
Recombinant Fusion Proteins--genetics
Surface Plasmon Resonance
Time Factors
Vaccines--immunology