Internalization and down-regulation of mu opioid receptors by endomorphins and morphine in SH-SY5Y human neuroblastoma cells.

Horner, Kristen A

Internalization and down-regulation of mu opioid receptors by endomorphins and morphine in SH-SY5Y human neuroblastoma cells. [electronic resource] - Brain research Dec 2004 - 121-32 p. digital

Publication Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.

0006-8993

10.1016/j.brainres.2004.07.055 doi


Analgesics, Opioid--pharmacokinetics
Binding Sites--drug effects
Cell Differentiation--drug effects
Cell Line, Tumor
Cell Membrane--drug effects
Dose-Response Relationship, Drug
Down-Regulation--drug effects
Drug Interactions
Endocytosis--drug effects
Enkephalin, Ala(2)-MePhe(4)-Gly(5)---pharmacokinetics
Humans
Hypotonic Solutions--pharmacology
Morphine--pharmacology
Narcotic Antagonists--pharmacokinetics
Neuroblastoma
Oligopeptides--pharmacology
Peptides--pharmacokinetics
Radioligand Assay--methods
Receptors, Opioid, mu--drug effects
Sucrose--pharmacology
Time Factors
Tritium--pharmacokinetics