Angiotensin II and epidermal growth factor induce cyclooxygenase-2 expression in intestinal epithelial cells through small GTPases using distinct signaling pathways.

Slice, Lee W

Angiotensin II and epidermal growth factor induce cyclooxygenase-2 expression in intestinal epithelial cells through small GTPases using distinct signaling pathways. [electronic resource] - The Journal of biological chemistry Jan 2005 - 1582-93 p. digital

Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.

0021-9258

10.1074/jbc.M408172200 doi


Angiotensin II--pharmacology
Animals
Cell Line
Cyclooxygenase 2
Dose-Response Relationship, Drug
Epidermal Growth Factor--pharmacology
Epithelial Cells--drug effects
Epoprostenol--biosynthesis
Gene Expression Regulation, Enzymologic--drug effects
Intestines--cytology
Mitogen-Activated Protein Kinases--metabolism
Monomeric GTP-Binding Proteins--metabolism
Prostaglandin-Endoperoxide Synthases--genetics
RNA, Messenger--genetics
Rats
Receptor, Angiotensin, Type 1--metabolism
Signal Transduction--drug effects
Time Factors
Transcription, Genetic--drug effects
cdc42 GTP-Binding Protein--metabolism