Long-term restoration of nigrostriatal system function by implanting GDNF genetically modified fibroblasts in a rat model of Parkinson's disease.

Duan, Deyi

Long-term restoration of nigrostriatal system function by implanting GDNF genetically modified fibroblasts in a rat model of Parkinson's disease. [electronic resource] - Experimental brain research Mar 2005 - 316-24 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0014-4819

10.1007/s00221-004-2075-y doi


Animals
Cell Count
Cells, Cultured
Corpus Striatum--metabolism
Disease Models, Animal
Dopamine--metabolism
Female
Fibroblasts--transplantation
Genetic Therapy--methods
Glial Cell Line-Derived Neurotrophic Factor
Humans
Nerve Growth Factors--biosynthesis
Neural Pathways--metabolism
Oxidopamine
Parkinsonian Disorders--chemically induced
Rats
Rats, Sprague-Dawley
Recovery of Function--physiology
Substantia Nigra--metabolism
Tissue Transplantation--methods
Treatment Outcome
Tyrosine 3-Monooxygenase--metabolism
Up-Regulation--physiology