Influence of hepatic and intestinal cytochrome P4503A activity on the acute disposition and effects of oral transmucosal fentanyl citrate.

Kharasch, Evan D

Influence of hepatic and intestinal cytochrome P4503A activity on the acute disposition and effects of oral transmucosal fentanyl citrate. [electronic resource] - Anesthesiology Sep 2004 - 729-37 p. digital

Publication Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S.

0003-3022

10.1097/00000542-200409000-00022 doi


Adult
Analgesics, Opioid--administration & dosage
Antibiotics, Antitubercular--pharmacology
Antiemetics--pharmacology
Area Under Curve
Aryl Hydrocarbon Hydroxylases--metabolism
Beverages
Chromatography, High Pressure Liquid
Citrus
Cross-Over Studies
Cytochrome P-450 CYP3A
Drug Interactions
Female
Fentanyl--administration & dosage
Food-Drug Interactions
Half-Life
Humans
Intestines--enzymology
Liver--enzymology
Male
Oxidoreductases, N-Demethylating--metabolism
Pupil--drug effects
Rifampin--pharmacology
Spectrometry, Mass, Electrospray Ionization
Troleandomycin--pharmacology