HLA-A*0201-restricted cytolytic responses to the rtTA transactivator dominant and cryptic epitopes compromise transgene expression induced by the tetracycline on system.

Ginhoux, F

HLA-A*0201-restricted cytolytic responses to the rtTA transactivator dominant and cryptic epitopes compromise transgene expression induced by the tetracycline on system. [electronic resource] - Molecular therapy : the journal of the American Society of Gene Therapy Aug 2004 - 279-89 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1525-0016

10.1016/j.ymthe.2004.05.012 doi


Alkaline Phosphatase--genetics
Animals
Doxycycline--pharmacology
Epitopes, T-Lymphocyte--genetics
Gene Expression--drug effects
Gene Expression Regulation
Genetic Therapy--methods
HLA-A Antigens--genetics
HLA-A2 Antigen
Immunodominant Epitopes--genetics
Mice
Mice, Transgenic
Muscle, Skeletal--immunology
Mutagenesis--genetics
Mutation--genetics
Peptides--genetics
T-Lymphocytes, Cytotoxic--immunology
Tetracycline--pharmacology
Trans-Activators--genetics
Transgenes--genetics