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Huang, Shyhmin

Dual-agent molecular targeting of the epidermal growth factor receptor (EGFR): combining anti-EGFR antibody with tyrosine kinase inhibitor. [electronic resource] - Cancer research Aug 2004 - 5355-62 p. digital

Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

ISSN: 0008-5472

Standard No.: 10.1158/0008-5472.CAN-04-0562 doi

Subjects--Topical Terms:
Animals
Antibodies, Monoclonal--administration & dosage
Antibodies, Monoclonal, Humanized
Antineoplastic Combined Chemotherapy Protocols--therapeutic use
Apoptosis--drug effects
Carcinoma, Non-Small-Cell Lung--drug therapy
Carcinoma, Squamous Cell--drug therapy
Cell Division--drug effects
Cetuximab
Enzyme Inhibitors--pharmacology
ErbB Receptors--antagonists & inhibitors
Erlotinib Hydrochloride
Female
Flow Cytometry
Gefitinib
Head and Neck Neoplasms--drug therapy
Humans
Immunoblotting
Lung Neoplasms--drug therapy
Male
Mice
Mitogen-Activated Protein Kinases--metabolism
Phosphorylation--drug effects
Proliferating Cell Nuclear Antigen--metabolism
Prostatic Neoplasms--drug therapy
Protein Serine-Threonine Kinases--metabolism
Protein-Tyrosine Kinases--antagonists & inhibitors
Proto-Oncogene Proteins--metabolism
Proto-Oncogene Proteins c-akt
Quinazolines--administration & dosage
Transplantation, Heterologous
Tumor Cells, Cultured