ATM-dependent CHK2 activation induced by anticancer agent, irofulven.

Wang, Jian

ATM-dependent CHK2 activation induced by anticancer agent, irofulven. [electronic resource] - The Journal of biological chemistry Sep 2004 - 39584-92 p. digital

Publication Type: Journal Article

0021-9258

10.1074/jbc.M400015200 doi


Antineoplastic Agents, Alkylating--pharmacology
Ataxia Telangiectasia Mutated Proteins
Cell Cycle Proteins--metabolism
Cell Line, Tumor
Checkpoint Kinase 1
Checkpoint Kinase 2
Chromosomal Proteins, Non-Histone--metabolism
DNA-Binding Proteins
Female
Humans
Nuclear Proteins--metabolism
Ovarian Neoplasms
Phosphorylation--drug effects
Protein Kinases--metabolism
Protein Serine-Threonine Kinases--metabolism
S Phase--drug effects
Serine--metabolism
Sesquiterpenes--pharmacology
Signal Transduction--drug effects
Tumor Suppressor Protein p53--metabolism
Tumor Suppressor Proteins
Structural Maintenance of Chromosome Protein 1