Free fatty acids promote hepatic lipotoxicity by stimulating TNF-alpha expression via a lysosomal pathway.

Feldstein, Ariel E

Free fatty acids promote hepatic lipotoxicity by stimulating TNF-alpha expression via a lysosomal pathway. [electronic resource] - Hepatology (Baltimore, Md.) Jul 2004 - 185-94 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

0270-9139

10.1002/hep.20283 doi


Animals
Antigens, CD--metabolism
Cathepsin B--metabolism
Cells, Cultured
Cytosol--metabolism
Diet--adverse effects
Drug Combinations
Fatty Acids, Nonesterified--physiology
Fatty Liver--etiology
Humans
Liver--drug effects
Lysosomes--metabolism
Mice
Mice, Knockout
NF-kappa B--metabolism
Oleic Acid--poisoning
Palmitates--poisoning
Proto-Oncogene Proteins--metabolism
Proto-Oncogene Proteins c-bcl-2
Receptors, Tumor Necrosis Factor--metabolism
Receptors, Tumor Necrosis Factor, Type I
Severity of Illness Index
Tissue Distribution
Tumor Necrosis Factor-alpha--metabolism
bcl-2-Associated X Protein