Akt/protein kinase B signaling inhibitor-2, a selective small molecule inhibitor of Akt signaling with antitumor activity in cancer cells overexpressing Akt.

Yang, Lin

Akt/protein kinase B signaling inhibitor-2, a selective small molecule inhibitor of Akt signaling with antitumor activity in cancer cells overexpressing Akt. [electronic resource] - Cancer research Jul 2004 - 4394-9 p. digital

Publication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.

0008-5472

10.1158/0008-5472.CAN-04-0343 doi


Animals
Apoptosis--drug effects
Cell Division--drug effects
Cell Line, Tumor
Cyclic AMP-Dependent Protein Kinases--antagonists & inhibitors
Enzyme Inhibitors--pharmacology
Female
Humans
Immediate-Early Proteins
JNK Mitogen-Activated Protein Kinases
MAP Kinase Signaling System--drug effects
Mice
Mice, Nude
Mitogen-Activated Protein Kinases--antagonists & inhibitors
NIH 3T3 Cells
Nuclear Proteins
Nucleosides--pharmacology
Protein Kinase C--antagonists & inhibitors
Protein Serine-Threonine Kinases--antagonists & inhibitors
Proto-Oncogene Proteins--antagonists & inhibitors
Proto-Oncogene Proteins c-akt
Pyridazines--pharmacology
Signal Transduction--drug effects
Substrate Specificity
Xenograft Model Antitumor Assays
p38 Mitogen-Activated Protein Kinases