Inhibition of ICAM-1 gene expression, monocyte adhesion and cancer cell invasion by targeting IKK complex: molecular and functional study of novel alpha-methylene-gamma-butyrolactone derivatives.

Huang, Wei-Chien

Inhibition of ICAM-1 gene expression, monocyte adhesion and cancer cell invasion by targeting IKK complex: molecular and functional study of novel alpha-methylene-gamma-butyrolactone derivatives. [electronic resource] - Carcinogenesis Oct 2004 - 1925-34 p. digital

Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

0143-3334

10.1093/carcin/bgh211 doi


4-Butyrolactone--analogs & derivatives
Anti-Ulcer Agents--pharmacology
Cell Adhesion--drug effects
Cyclooxygenase 2
Electrophoretic Mobility Shift Assay
Epithelial Cells--drug effects
Gene Expression Regulation--drug effects
Humans
I-kappa B Kinase
Intercellular Adhesion Molecule-1--genetics
Isoenzymes--metabolism
Luciferases--metabolism
Matrix Metalloproteinase 9--metabolism
Membrane Proteins
Mitogen-Activated Protein Kinase 1--metabolism
Mitogen-Activated Protein Kinase 3
Mitogen-Activated Protein Kinases--metabolism
Monocytes--metabolism
NF-kappa B--metabolism
Neoplasm Invasiveness--pathology
Phosphorylation--drug effects
Promoter Regions, Genetic--drug effects
Prostaglandin-Endoperoxide Synthases--metabolism
Protein Serine-Threonine Kinases--drug effects
Reverse Transcriptase Polymerase Chain Reaction
Tumor Necrosis Factor-alpha--pharmacology
U937 Cells--drug effects
p38 Mitogen-Activated Protein Kinases
NF-kappaB-Inducing Kinase