Overexpression of collagenase 1 (MMP-1) is mediated by the ERK pathway in invasive melanoma cells: role of BRAF mutation and fibroblast growth factor signaling.

Huntington, Jonathan T

Overexpression of collagenase 1 (MMP-1) is mediated by the ERK pathway in invasive melanoma cells: role of BRAF mutation and fibroblast growth factor signaling. [electronic resource] - The Journal of biological chemistry Aug 2004 - 33168-76 p. digital

Publication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.

0021-9258

10.1074/jbc.M405102200 doi


Arsenites--pharmacology
Disease-Free Survival
Enzyme Activation--drug effects
Fibroblast Growth Factors--metabolism
Gene Expression
Humans
MAP Kinase Kinase 1
MAP Kinase Kinase 2
Matrix Metalloproteinase 1--analysis
Melanoma--enzymology
Mitogen-Activated Protein Kinase 1--metabolism
Mitogen-Activated Protein Kinase 3
Mitogen-Activated Protein Kinase Kinases--metabolism
Mitogen-Activated Protein Kinases--metabolism
Mutation
Neoplasm Invasiveness
Phosphorylation
Prognosis
Protein-Tyrosine Kinases--metabolism
Proto-Oncogene Proteins B-raf
Proto-Oncogene Proteins c-raf--genetics
RNA, Messenger--analysis
Reverse Transcriptase Polymerase Chain Reaction
Signal Transduction
Sodium Compounds--pharmacology
Tumor Cells, Cultured