Altered cortical synaptic morphology and impaired memory consolidation in forebrain- specific dominant-negative PAK transgenic mice.

Hayashi, Mansuo L

Altered cortical synaptic morphology and impaired memory consolidation in forebrain- specific dominant-negative PAK transgenic mice. [electronic resource] - Neuron Jun 2004 - 773-87 p. digital

Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

0896-6273

10.1016/j.neuron.2004.05.003 doi


Analysis of Variance
Animals
Animals, Newborn
Behavior, Animal
Blotting, Northern--methods
Blotting, Western--methods
Dendrites--pathology
Drug Interactions
Enzyme Activation
Excitatory Amino Acid Agonists--pharmacology
Excitatory Amino Acid Antagonists--pharmacology
Glycine--pharmacology
Hippocampus--pathology
Immunohistochemistry--methods
In Situ Hybridization--methods
Long-Term Potentiation
Long-Term Synaptic Depression
Male
Maze Learning--physiology
Memory Disorders--genetics
Mice
Mice, Inbred C57BL
Mice, Transgenic
Microscopy, Electron--methods
Models, Neurological
Nerve Tissue Proteins--drug effects
Neurofilament Proteins--metabolism
Neurons--classification
Prosencephalon--pathology
Protein Serine-Threonine Kinases--genetics
Proto-Oncogene Proteins c-myc--metabolism
Rats
Retention, Psychology--drug effects
Silver Staining--methods
Spatial Behavior--physiology
Synapses--pathology
Synaptophysin--metabolism
Time Factors
Valine--analogs & derivatives
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid--pharmacology
p21-Activated Kinases