Isohumulones, bitter acids derived from hops, activate both peroxisome proliferator-activated receptor alpha and gamma and reduce insulin resistance.

Yajima, Hiroaki

Isohumulones, bitter acids derived from hops, activate both peroxisome proliferator-activated receptor alpha and gamma and reduce insulin resistance. [electronic resource] - The Journal of biological chemistry Aug 2004 - 33456-62 p. digital

Publication Type: Clinical Trial; Journal Article; Randomized Controlled Trial

0021-9258

10.1074/jbc.M403456200 doi


Aged
Animals
Blood Glucose--analysis
Body Weight--drug effects
Cyclopentanes--pharmacology
DNA-Binding Proteins
Diabetes Mellitus, Type 2--blood
Dietary Fats--administration & dosage
Double-Blind Method
Fatty Acids, Nonesterified--blood
Female
Glycated Hemoglobin--analysis
Humans
Humulus--chemistry
Insulin Resistance--physiology
Lipoprotein Lipase--genetics
Male
Mice
Mice, Inbred C57BL
Middle Aged
Pilot Projects
Pioglitazone
Placebos
Plant Extracts--chemistry
RNA, Messenger--analysis
Receptors, Cytoplasmic and Nuclear--drug effects
Recombinant Fusion Proteins
Saccharomyces cerevisiae Proteins--genetics
Thiazolidinediones--pharmacology
Transcription Factors--drug effects
Transfection
Triglycerides--blood
Weight Gain