Olanzapine produces trophic effects in vitro and stimulates phosphorylation of Akt/PKB, ERK1/2, and the mitogen-activated protein kinase p38.

Lu, Xiao-Hong

Olanzapine produces trophic effects in vitro and stimulates phosphorylation of Akt/PKB, ERK1/2, and the mitogen-activated protein kinase p38. [electronic resource] - Brain research Jun 2004 - 58-68 p. digital

Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

0006-8993

10.1016/j.brainres.2004.03.018 doi


3-Phosphoinositide-Dependent Protein Kinases
Amyloid beta-Peptides--pharmacology
Animals
Antipsychotic Agents--pharmacology
Benzodiazepines--pharmacology
Blotting, Western--methods
Bromodeoxyuridine--metabolism
Cell Division--drug effects
Cells, Cultured
Cerebral Cortex--cytology
Culture Media, Serum-Free--pharmacology
Dose-Response Relationship, Drug
Drug Interactions
Enzyme Activation--drug effects
Enzyme Inhibitors--pharmacology
Humans
Mice
Mitogen-Activated Protein Kinase 1--metabolism
Mitogen-Activated Protein Kinase 3
Mitogen-Activated Protein Kinases--metabolism
Neuroblastoma
Neurons--drug effects
Olanzapine
Peptide Fragments--pharmacology
Pertussis Toxin--pharmacology
Phosphorylation--drug effects
Protein Serine-Threonine Kinases--metabolism
Rats
Tetrazolium Salts
Thiazoles
Time Factors
p38 Mitogen-Activated Protein Kinases