Downregulation of Bcl-2, FLIP or IAPs (XIAP and survivin) by siRNAs sensitizes resistant melanoma cells to Apo2L/TRAIL-induced apoptosis.

Chawla-Sarkar, M

Downregulation of Bcl-2, FLIP or IAPs (XIAP and survivin) by siRNAs sensitizes resistant melanoma cells to Apo2L/TRAIL-induced apoptosis. [electronic resource] - Cell death and differentiation Aug 2004 - 915-23 p. digital

Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.

1350-9047

10.1038/sj.cdd.4401416 doi


Animals
Apoptosis--drug effects
Apoptosis Regulatory Proteins
BH3 Interacting Domain Death Agonist Protein
CASP8 and FADD-Like Apoptosis Regulating Protein
Carrier Proteins--metabolism
Caspase 9
Caspases--metabolism
Genes, bcl-2--physiology
Humans
Inhibitor of Apoptosis Proteins
Intracellular Signaling Peptides and Proteins--metabolism
Melanoma--metabolism
Membrane Glycoproteins--metabolism
Microtubule-Associated Proteins--metabolism
Neoplasm Proteins
Proteins--metabolism
RNA, Small Interfering--genetics
Survivin
TNF-Related Apoptosis-Inducing Ligand
Tumor Cells, Cultured
Tumor Necrosis Factor-alpha--pharmacology
X-Linked Inhibitor of Apoptosis Protein