Tranilast attenuates myocardial fibrosis in association with suppression of monocyte/macrophage infiltration in DOCA/salt hypertensive rats.

Kagitani, Satoshi

Tranilast attenuates myocardial fibrosis in association with suppression of monocyte/macrophage infiltration in DOCA/salt hypertensive rats. [electronic resource] - Journal of hypertension May 2004 - 1007-15 p. digital

Publication Type: Journal Article

0263-6352

10.1097/00004872-200405000-00024 doi


Animals
Anti-Inflammatory Agents, Non-Steroidal--pharmacology
Blood Pressure
Body Weight
Cardiomegaly--drug therapy
Chemokine CCL2--genetics
Collagen Type I--genetics
Collagen Type III--genetics
Desoxycorticosterone--pharmacology
Fibrosis
Hypertension--complications
Interleukin-6--genetics
Macrophages--immunology
Male
Monocytes--immunology
Myocardium--pathology
Nephrectomy
Organ Size
Plasminogen Activator Inhibitor 1--genetics
RNA, Messenger--analysis
Rats
Rats, Sprague-Dawley
Sodium Chloride, Dietary--pharmacology
Transforming Growth Factor beta--genetics
Transforming Growth Factor beta1
ortho-Aminobenzoates--pharmacology