New alpha(1)-adrenoceptor antagonists derived from the antipsychotic sertindole - carbon-11 labelling and pet examination of brain uptake in the cynomolgus monkey.
Balle, Thomas
New alpha(1)-adrenoceptor antagonists derived from the antipsychotic sertindole - carbon-11 labelling and pet examination of brain uptake in the cynomolgus monkey. [electronic resource] - Nuclear medicine and biology Apr 2004 - 327-36 p. digital
Publication Type: Comparative Study; Evaluation Study; Journal Article
0969-8051
10.1016/j.nucmedbio.2003.08.012 doi
ATP Binding Cassette Transporter, Subfamily B, Member 1--deficiency
Adrenergic alpha-1 Receptor Antagonists
Animals
Antipsychotic Agents--chemistry
Brain--diagnostic imaging
Caco-2 Cells
Carbon Radioisotopes--chemistry
Cyclosporine--pharmacology
Drug Evaluation, Preclinical
Humans
Imidazoles--chemistry
Indoles--chemistry
Isotope Labeling--methods
Kinetics
Macaca fascicularis
Male
Metabolic Clearance Rate
Mice
Positron-Emission Tomography--methods
Protein Binding
Radiopharmaceuticals--chemical synthesis
Receptors, Adrenergic, alpha-1--metabolism
New alpha(1)-adrenoceptor antagonists derived from the antipsychotic sertindole - carbon-11 labelling and pet examination of brain uptake in the cynomolgus monkey. [electronic resource] - Nuclear medicine and biology Apr 2004 - 327-36 p. digital
Publication Type: Comparative Study; Evaluation Study; Journal Article
0969-8051
10.1016/j.nucmedbio.2003.08.012 doi
ATP Binding Cassette Transporter, Subfamily B, Member 1--deficiency
Adrenergic alpha-1 Receptor Antagonists
Animals
Antipsychotic Agents--chemistry
Brain--diagnostic imaging
Caco-2 Cells
Carbon Radioisotopes--chemistry
Cyclosporine--pharmacology
Drug Evaluation, Preclinical
Humans
Imidazoles--chemistry
Indoles--chemistry
Isotope Labeling--methods
Kinetics
Macaca fascicularis
Male
Metabolic Clearance Rate
Mice
Positron-Emission Tomography--methods
Protein Binding
Radiopharmaceuticals--chemical synthesis
Receptors, Adrenergic, alpha-1--metabolism