Toward an HDAC6 inhibitor: synthesis and conformational analysis of cyclic hexapeptide hydroxamic acid designed from alpha-tubulin sequence.

Jose, Binoy

Toward an HDAC6 inhibitor: synthesis and conformational analysis of cyclic hexapeptide hydroxamic acid designed from alpha-tubulin sequence. [electronic resource] - Bioorganic & medicinal chemistry Mar 2004 - 1351-6 p. digital

Publication Type: Comparative Study; Journal Article

0968-0896

10.1016/j.bmc.2004.01.014 doi


Acetylation
Enzyme Inhibitors--chemical synthesis
Histone Deacetylase 6
Histone Deacetylase Inhibitors
Histone Deacetylases--metabolism
Humans
Hydroxamic Acids--chemical synthesis
Lysine--chemistry
Peptides, Cyclic--chemical synthesis
Protein Conformation
Structure-Activity Relationship
Tubulin--chemistry