Synthesis, characterization, and preliminary in vivo tests of new poly(ethylene glycol) conjugates of the antitumor agent 10-amino-7-ethylcamptothecin.

Guiotto, Andrea

Synthesis, characterization, and preliminary in vivo tests of new poly(ethylene glycol) conjugates of the antitumor agent 10-amino-7-ethylcamptothecin. [electronic resource] - Journal of medicinal chemistry Feb 2004 - 1280-9 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0022-2623

10.1021/jm031072e doi


Animals
Antineoplastic Agents--chemical synthesis
Camptothecin--analogs & derivatives
Cathepsin B--chemistry
Cell Line, Tumor
Drug Resistance, Neoplasm
Drug Screening Assays, Antitumor
Hydrolysis
Male
Mice
Oligopeptides--chemical synthesis
Polyethylene Glycols--chemistry
Prodrugs--chemical synthesis
Rats
Rats, Sprague-Dawley
Structure-Activity Relationship