Synthesis and biological evaluation of new selective cytotoxic cyclolignans derived from podophyllotoxin.

Castro, María Angeles

Synthesis and biological evaluation of new selective cytotoxic cyclolignans derived from podophyllotoxin. [electronic resource] - Journal of medicinal chemistry Feb 2004 - 1214-22 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0022-2623

10.1021/jm030978h doi


Animals
Antineoplastic Agents--chemical synthesis
Apoptosis--drug effects
Cell Cycle--drug effects
Cell Line, Tumor
Drug Screening Assays, Antitumor
Humans
Imines--chemical synthesis
Mice
Podophyllotoxin--analogs & derivatives
Structure-Activity Relationship