Synthesis and chemical-pharmacological characterization of the antimetastatic NAMI-A-type Ru(III) complexes (Hdmtp)[trans-RuCl4(dmso-S)(dmtp)], (Na)[trans-RuCl4(dmso-S)(dmtp)], and [mer-RuCl3(H2O)(dmso-S)(dmtp)] (dmtp = 5,7-dimethyl[1,2,4]triazolo[1,5-a]pyrimidine).

Velders, Aldrik H

Synthesis and chemical-pharmacological characterization of the antimetastatic NAMI-A-type Ru(III) complexes (Hdmtp)[trans-RuCl4(dmso-S)(dmtp)], (Na)[trans-RuCl4(dmso-S)(dmtp)], and [mer-RuCl3(H2O)(dmso-S)(dmtp)] (dmtp = 5,7-dimethyl[1,2,4]triazolo[1,5-a]pyrimidine). [electronic resource] - Journal of medicinal chemistry Feb 2004 - 1110-21 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0022-2623

10.1021/jm030984d doi


Animals
Antineoplastic Agents--chemical synthesis
Cell Cycle--drug effects
Cell Line, Tumor
Cell Survival--drug effects
Crystallography, X-Ray
Drug Screening Assays, Antitumor
Hydrolysis
Kidney--drug effects
Liver--drug effects
Lung Neoplasms--drug therapy
Magnetic Resonance Spectroscopy
Mammary Neoplasms, Animal--pathology
Matrix Metalloproteinase 9--chemistry
Mice
Molecular Structure
Neoplasm Invasiveness
Neoplasm Metastasis--prevention & control
Organometallic Compounds--chemical synthesis
Ruthenium--pharmacokinetics
Spectrophotometry, Ultraviolet
Structure-Activity Relationship
Tissue Distribution