New class of bacterial phenylalanyl-tRNA synthetase inhibitors with high potency and broad-spectrum activity.

Beyer, Dieter

New class of bacterial phenylalanyl-tRNA synthetase inhibitors with high potency and broad-spectrum activity. [electronic resource] - Antimicrobial agents and chemotherapy Feb 2004 - 525-32 p. digital

Publication Type: Journal Article

0066-4804

10.1128/AAC.48.2.525-532.2004 doi


Animals
Anti-Bacterial Agents--pharmacology
Bacillus subtilis--drug effects
Bacteria--drug effects
CHO Cells
Colony Count, Microbial
Cricetinae
Drug Design
Enzyme Inhibitors--pharmacology
Escherichia coli--drug effects
Female
Gram-Negative Bacteria--drug effects
Gram-Positive Bacteria--drug effects
Mice
Microbial Sensitivity Tests
Pneumococcal Infections--drug therapy
Proteome--genetics
Rats
Rats, Wistar
Staphylococcal Infections--drug therapy
Substrate Specificity