Farnesyltransferase inhibitor tipifarnib is well tolerated, induces stabilization of disease, and inhibits farnesylation and oncogenic/tumor survival pathways in patients with advanced multiple myeloma.
Alsina, Melissa
Farnesyltransferase inhibitor tipifarnib is well tolerated, induces stabilization of disease, and inhibits farnesylation and oncogenic/tumor survival pathways in patients with advanced multiple myeloma. [electronic resource] - Blood May 2004 - 3271-7 p. digital
Publication Type: Clinical Trial; Clinical Trial, Phase II; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
0006-4971
10.1182/blood-2003-08-2764 doi
Adult
Aged
Aged, 80 and over
Alkyl and Aryl Transferases--antagonists & inhibitors
Carrier Proteins--metabolism
Cell Survival--drug effects
DNA-Binding Proteins--metabolism
Disease Progression
Farnesyltranstransferase
Female
HSP40 Heat-Shock Proteins
Heat-Shock Proteins--metabolism
Humans
Male
Middle Aged
Mitogen-Activated Protein Kinase 1--metabolism
Mitogen-Activated Protein Kinase 3
Mitogen-Activated Protein Kinases--metabolism
Multiple Myeloma--complications
Phosphorylation--drug effects
Protein Prenylation--drug effects
Protein Serine-Threonine Kinases
Proto-Oncogene Proteins--metabolism
Proto-Oncogene Proteins c-akt
Quinolones--administration & dosage
STAT3 Transcription Factor
Salvage Therapy
Signal Transduction--drug effects
Trans-Activators--metabolism
ras Proteins--metabolism
Farnesyltransferase inhibitor tipifarnib is well tolerated, induces stabilization of disease, and inhibits farnesylation and oncogenic/tumor survival pathways in patients with advanced multiple myeloma. [electronic resource] - Blood May 2004 - 3271-7 p. digital
Publication Type: Clinical Trial; Clinical Trial, Phase II; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
0006-4971
10.1182/blood-2003-08-2764 doi
Adult
Aged
Aged, 80 and over
Alkyl and Aryl Transferases--antagonists & inhibitors
Carrier Proteins--metabolism
Cell Survival--drug effects
DNA-Binding Proteins--metabolism
Disease Progression
Farnesyltranstransferase
Female
HSP40 Heat-Shock Proteins
Heat-Shock Proteins--metabolism
Humans
Male
Middle Aged
Mitogen-Activated Protein Kinase 1--metabolism
Mitogen-Activated Protein Kinase 3
Mitogen-Activated Protein Kinases--metabolism
Multiple Myeloma--complications
Phosphorylation--drug effects
Protein Prenylation--drug effects
Protein Serine-Threonine Kinases
Proto-Oncogene Proteins--metabolism
Proto-Oncogene Proteins c-akt
Quinolones--administration & dosage
STAT3 Transcription Factor
Salvage Therapy
Signal Transduction--drug effects
Trans-Activators--metabolism
ras Proteins--metabolism