Selective prion protein binding to synaptic components is modulated by oxidative and nitrosative changes induced by copper(II) and peroxynitrite in cholinergic synaptosomes, unveiling a role for calcineurin B and thioredoxin.

Morot-Gaudry-Talarmain, Y

Selective prion protein binding to synaptic components is modulated by oxidative and nitrosative changes induced by copper(II) and peroxynitrite in cholinergic synaptosomes, unveiling a role for calcineurin B and thioredoxin. [electronic resource] - Journal of neurochemistry Dec 2003 - 1456-70 p. digital

Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

0022-3042

10.1046/j.1471-4159.2003.02111.x doi


14-3-3 Proteins
Animals
Blotting, Western--methods
Calcineurin--metabolism
Carbocyanines--metabolism
Choline O-Acetyltransferase--metabolism
Copper Sulfate--pharmacology
Cyclophilin A--metabolism
Cysteine--analogs & derivatives
Dose-Response Relationship, Drug
Epitopes--chemistry
Humans
In Vitro Techniques
Membrane Glycoproteins--metabolism
Membrane Proteins--metabolism
Mercaptoethanol--pharmacology
Nerve Tissue Proteins--metabolism
Neurons--cytology
Nitrosation--drug effects
Oxidation-Reduction--drug effects
Peroxynitrous Acid--pharmacology
Prions--chemistry
Protein Binding
Pyruvic Acid--pharmacology
Qa-SNARE Proteins
R-SNARE Proteins
Recombinant Proteins--metabolism
S-Nitrosothiols--metabolism
Sheep
Synapsins--metabolism
Synaptic Vesicles--drug effects
Synaptosomes--drug effects
Tacrolimus Binding Proteins--metabolism
Thioredoxins--metabolism
Time Factors
Torpedo
Tyrosine--analogs & derivatives
Tyrosine 3-Monooxygenase--metabolism