Lovastatin and mevastatin reduce basal and cytokine-stimulated production of prostaglandins from rat microglial cells in vitro: evidence for a mechanism unrelated to the inhibition of hydroxy-methyl-glutaryl CoA reductase.
Tringali, Giuseppe
Lovastatin and mevastatin reduce basal and cytokine-stimulated production of prostaglandins from rat microglial cells in vitro: evidence for a mechanism unrelated to the inhibition of hydroxy-methyl-glutaryl CoA reductase. [electronic resource] - Neuroscience letters Jan 2004 - 107-10 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
0304-3940
10.1016/j.neulet.2003.09.066 doi
Animals
Anti-Inflammatory Agents--pharmacology
Astrocytes--cytology
Autoimmune Diseases of the Nervous System--drug therapy
Cells, Cultured
Coculture Techniques
Cytokines--drug effects
Dinoprostone--antagonists & inhibitors
Down-Regulation--drug effects
Drug Synergism
Encephalitis--drug therapy
Hydroxymethylglutaryl CoA Reductases--metabolism
Hydroxymethylglutaryl-CoA Reductase Inhibitors--pharmacology
Interleukin-1--pharmacology
Lovastatin--analogs & derivatives
Mevalonic Acid--metabolism
Microglia--cytology
Polyisoprenyl Phosphates--metabolism
Prostaglandins--metabolism
Rats
Sesquiterpenes
Lovastatin and mevastatin reduce basal and cytokine-stimulated production of prostaglandins from rat microglial cells in vitro: evidence for a mechanism unrelated to the inhibition of hydroxy-methyl-glutaryl CoA reductase. [electronic resource] - Neuroscience letters Jan 2004 - 107-10 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
0304-3940
10.1016/j.neulet.2003.09.066 doi
Animals
Anti-Inflammatory Agents--pharmacology
Astrocytes--cytology
Autoimmune Diseases of the Nervous System--drug therapy
Cells, Cultured
Coculture Techniques
Cytokines--drug effects
Dinoprostone--antagonists & inhibitors
Down-Regulation--drug effects
Drug Synergism
Encephalitis--drug therapy
Hydroxymethylglutaryl CoA Reductases--metabolism
Hydroxymethylglutaryl-CoA Reductase Inhibitors--pharmacology
Interleukin-1--pharmacology
Lovastatin--analogs & derivatives
Mevalonic Acid--metabolism
Microglia--cytology
Polyisoprenyl Phosphates--metabolism
Prostaglandins--metabolism
Rats
Sesquiterpenes