Design, synthesis and biological activity of novel dimethyl-[2-[6-substituted-indol-1-yl]-ethyl]-amine as potent, selective, and orally-bioavailable 5-HT(1D) agonists.

Isaac, Methvin

Design, synthesis and biological activity of novel dimethyl-[2-[6-substituted-indol-1-yl]-ethyl]-amine as potent, selective, and orally-bioavailable 5-HT(1D) agonists. [electronic resource] - Bioorganic & medicinal chemistry letters Dec 2003 - 4409-13 p. digital

Publication Type: Journal Article

0960-894X

10.1016/j.bmcl.2003.09.025 doi


Administration, Oral
Amines--chemical synthesis
Binding Sites
Biological Availability
Drug Design
Humans
Indoles--chemical synthesis
Kinetics
Molecular Conformation
Receptor, Serotonin, 5-HT1B--chemistry
Serotonin Receptor Agonists--administration & dosage
Structure-Activity Relationship