AZD7545, a novel inhibitor of pyruvate dehydrogenase kinase 2 (PDHK2), activates pyruvate dehydrogenase in vivo and improves blood glucose control in obese (fa/fa) Zucker rats.

Mayers, R M

AZD7545, a novel inhibitor of pyruvate dehydrogenase kinase 2 (PDHK2), activates pyruvate dehydrogenase in vivo and improves blood glucose control in obese (fa/fa) Zucker rats. [electronic resource] - Biochemical Society transactions Dec 2003 - 1165-7 p. digital

Publication Type: Journal Article; Review

0300-5127

10.1042/bst0311165 doi


Animals
Blood Glucose--analysis
Enzyme Activation
Enzyme Inhibitors--pharmacology
Obesity--blood
Protein Kinase Inhibitors
Protein Kinases--metabolism
Protein Serine-Threonine Kinases
Pyruvate Dehydrogenase Acetyl-Transferring Kinase
Rats
Rats, Zucker