Connective tissue growth factor and igf-I are produced by human renal fibroblasts and cooperate in the induction of collagen production by high glucose.

Lam, Suzanne

Connective tissue growth factor and igf-I are produced by human renal fibroblasts and cooperate in the induction of collagen production by high glucose. [electronic resource] - Diabetes Dec 2003 - 2975-83 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0012-1797

10.2337/diabetes.52.12.2975 doi


Cells, Cultured
Collagen Type I--biosynthesis
Collagen Type III--biosynthesis
Connective Tissue Growth Factor
Dose-Response Relationship, Drug
Drug Synergism
Fibroblasts--drug effects
Glucose--administration & dosage
Humans
Immediate-Early Proteins--biosynthesis
Insulin-Like Growth Factor I--biosynthesis
Intercellular Signaling Peptides and Proteins--biosynthesis
Kidney--metabolism
Recombinant Proteins--pharmacology
Transforming Growth Factor beta--pharmacology
Transforming Growth Factor beta1