Impaired host defense to Klebsiella pneumoniae infection in mice treated with the PDE4 inhibitor rolipram.

Soares, A C

Impaired host defense to Klebsiella pneumoniae infection in mice treated with the PDE4 inhibitor rolipram. [electronic resource] - British journal of pharmacology Nov 2003 - 855-62 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0007-1188

10.1038/sj.bjp.0705517 doi


3',5'-Cyclic-AMP Phosphodiesterases--antagonists & inhibitors
Animals
Cyclic Nucleotide Phosphodiesterases, Type 4
Cytokines--immunology
Dose-Response Relationship, Drug
Enzyme Inhibitors--pharmacology
Female
Klebsiella Infections--immunology
Klebsiella pneumoniae--immunology
Mice
Mice, Inbred BALB C
Neutrophil Infiltration--drug effects
Rolipram--pharmacology