Grapefruit juice intake does not enhance but rather protects against aflatoxin B1-induced liver DNA damage through a reduction in hepatic CYP3A activity.

Miyata, Masaaki

Grapefruit juice intake does not enhance but rather protects against aflatoxin B1-induced liver DNA damage through a reduction in hepatic CYP3A activity. [electronic resource] - Carcinogenesis Feb 2004 - 203-9 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0143-3334

10.1093/carcin/bgg194 doi


Aflatoxin B1--toxicity
Animals
Aryl Hydrocarbon Hydroxylases--metabolism
Beverages
Citrus paradisi
Cytochrome P-450 CYP3A
DNA Damage--drug effects
Glutathione--metabolism
Glutathione Transferase--metabolism
Liver--drug effects
Male
Microsomes, Liver--enzymology
Oxidoreductases, N-Demethylating--metabolism
Rats
Rats, Inbred F344
Salmonella typhimurium--drug effects
Testosterone--metabolism