Akt activation disrupts mammary acinar architecture and enhances proliferation in an mTOR-dependent manner.
Debnath, Jayanta
Akt activation disrupts mammary acinar architecture and enhances proliferation in an mTOR-dependent manner. [electronic resource] - The Journal of cell biology Oct 2003 - 315-26 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
0021-9525
10.1083/jcb.200304159 doi
Antibiotics, Antineoplastic--pharmacology
Apoptosis
Breast--cytology
Cell Division--drug effects
Cell Line
Cell Line, Transformed
Cell Polarity--drug effects
Cell Size--drug effects
Cell Survival--drug effects
Cyclin D1--metabolism
DNA--analysis
Dose-Response Relationship, Drug
Enzyme Activation
Epithelial Cells--cytology
Humans
Morphogenesis--drug effects
Protein Kinase Inhibitors
Protein Kinases--drug effects
Protein Serine-Threonine Kinases
Proto-Oncogene Proteins--genetics
Proto-Oncogene Proteins c-akt
Retroviridae--genetics
Sirolimus--pharmacology
TOR Serine-Threonine Kinases
Akt activation disrupts mammary acinar architecture and enhances proliferation in an mTOR-dependent manner. [electronic resource] - The Journal of cell biology Oct 2003 - 315-26 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
0021-9525
10.1083/jcb.200304159 doi
Antibiotics, Antineoplastic--pharmacology
Apoptosis
Breast--cytology
Cell Division--drug effects
Cell Line
Cell Line, Transformed
Cell Polarity--drug effects
Cell Size--drug effects
Cell Survival--drug effects
Cyclin D1--metabolism
DNA--analysis
Dose-Response Relationship, Drug
Enzyme Activation
Epithelial Cells--cytology
Humans
Morphogenesis--drug effects
Protein Kinase Inhibitors
Protein Kinases--drug effects
Protein Serine-Threonine Kinases
Proto-Oncogene Proteins--genetics
Proto-Oncogene Proteins c-akt
Retroviridae--genetics
Sirolimus--pharmacology
TOR Serine-Threonine Kinases