Effects of the proteasome inhibitor, bortezomib, on apoptosis in isolated lymphocytes obtained from patients with chronic lymphocytic leukemia.

Pahler, Jessica C

Effects of the proteasome inhibitor, bortezomib, on apoptosis in isolated lymphocytes obtained from patients with chronic lymphocytic leukemia. [electronic resource] - Clinical cancer research : an official journal of the American Association for Cancer Research Oct 2003 - 4570-7 p. digital

Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

1078-0432


Antineoplastic Agents--pharmacology
Apoptosis--drug effects
Boronic Acids--pharmacology
Bortezomib
Caspases--metabolism
Complement Membrane Attack Complex
Complement System Proteins
Cysteine Endopeptidases--drug effects
Cytochromes c--metabolism
DNA (Cytosine-5-)-Methyltransferases--antagonists & inhibitors
Drug Resistance, Neoplasm
Enzyme Activation
Glucocorticoids--pharmacology
Glycoproteins--metabolism
Humans
Inhibitor of Apoptosis Proteins
Leukemia, Lymphocytic, Chronic, B-Cell--drug therapy
Lymphocytes--drug effects
Mitochondria--drug effects
Multienzyme Complexes--drug effects
Neoplasm Recurrence, Local--drug therapy
Protease Inhibitors--pharmacology
Proteasome Endopeptidase Complex
Proteins--metabolism
Pyrazines--pharmacology
Tumor Cells, Cultured
Vidarabine--analogs & derivatives
X-Linked Inhibitor of Apoptosis Protein