Adenovirus-mediated transfer of the PTEN gene inhibits human colorectal cancer growth in vitro and in vivo.

Saito, Y

Adenovirus-mediated transfer of the PTEN gene inhibits human colorectal cancer growth in vitro and in vivo. [electronic resource] - Gene therapy Nov 2003 - 1961-9 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

0969-7128

10.1038/sj.gt.3302100 doi


Adenoviridae--genetics
Animals
Apoptosis--genetics
Blotting, Western--methods
Caspases--metabolism
Cell Cycle--genetics
Cell Division--genetics
Colorectal Neoplasms--metabolism
DNA-Binding Proteins--genetics
Enzyme Activation
Forkhead Box Protein O1
Forkhead Transcription Factors
Gene Expression
Genetic Therapy--methods
Genetic Vectors--administration & dosage
Glycogen Synthase Kinase 3--genetics
Humans
Mice
Mice, Nude
Neoplasm Transplantation
PTEN Phosphohydrolase
Phosphoric Monoester Hydrolases--genetics
Protein Serine-Threonine Kinases
Proto-Oncogene Proteins--genetics
Proto-Oncogene Proteins c-akt
Transcription Factors--genetics
Transplantation, Heterologous
Tumor Suppressor Proteins--genetics