Pharmacological characterization of RS-1259, an orally active dual inhibitor of acetylcholinesterase and serotonin transporter, in rodents: possible treatment of Alzheimer's disease.

Abe, Yasuyuki

Pharmacological characterization of RS-1259, an orally active dual inhibitor of acetylcholinesterase and serotonin transporter, in rodents: possible treatment of Alzheimer's disease. [electronic resource] - Journal of pharmacological sciences Sep 2003 - 95-105 p. digital

Publication Type: Comparative Study; Journal Article

1347-8613

10.1254/jphs.93.95 doi


Acetylcholinesterase--metabolism
Administration, Oral
Aging--drug effects
Alzheimer Disease--drug therapy
Animals
Carbamates--chemistry
Carrier Proteins--antagonists & inhibitors
Cholinesterase Inhibitors--chemistry
Fumarates--chemistry
Hippocampus--drug effects
Male
Maze Learning--drug effects
Membrane Glycoproteins--antagonists & inhibitors
Membrane Transport Proteins
Memory--drug effects
Mice
Microdialysis
Motor Activity--drug effects
Nerve Tissue Proteins--antagonists & inhibitors
Rats
Rats, Inbred F344
Rats, Sprague-Dawley
Rats, Wistar
Serotonin Plasma Membrane Transport Proteins