Effects of the modulating agent WR2721 and its main metabolites on the formation and stability of cisplatin-DNA adducts in vitro in comparison to the effects of thiosulphate and diethyldithiocarbamate.

Treskes, M

Effects of the modulating agent WR2721 and its main metabolites on the formation and stability of cisplatin-DNA adducts in vitro in comparison to the effects of thiosulphate and diethyldithiocarbamate. [electronic resource] - Biochemical pharmacology Mar 1992 - 1013-9 p. digital

Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

0006-2952

10.1016/0006-2952(92)90607-k doi


Amifostine--metabolism
Animals
Buffers
Cisplatin--metabolism
DNA--metabolism
DNA Adducts
Ditiocarb--pharmacology
Hydrogen-Ion Concentration
Mercaptoethylamines--metabolism
Salmon
Thiosulfates--pharmacology