NAD(P)H (quinone acceptor) oxidoreductase (DT-diaphorase)-mediated two-electron reduction of anthraquinone-based antitumour agents and generation of hydroxyl radicals.

Fisher, G R

NAD(P)H (quinone acceptor) oxidoreductase (DT-diaphorase)-mediated two-electron reduction of anthraquinone-based antitumour agents and generation of hydroxyl radicals. [electronic resource] - Biochemical pharmacology Feb 1992 - 575-85 p. digital

Publication Type: Journal Article

0006-2952

10.1016/0006-2952(92)90581-3 doi


Animals
Anthraquinones--pharmacology
Antineoplastic Agents--pharmacology
Daunorubicin--pharmacology
Dose-Response Relationship, Drug
Hydroxides--metabolism
Hydroxyl Radical
Kinetics
Liver--enzymology
Mitoxantrone--analogs & derivatives
NAD(P)H Dehydrogenase (Quinone)--isolation & purification
NADP--metabolism
Oxidation-Reduction
Rats
Structure-Activity Relationship
Superoxides--metabolism