Deletion, but not antagonism, of the mouse growth hormone receptor results in severely decreased body weights, insulin, and insulin-like growth factor I levels and increased life span.

Coschigano, Karen T

Deletion, but not antagonism, of the mouse growth hormone receptor results in severely decreased body weights, insulin, and insulin-like growth factor I levels and increased life span. [electronic resource] - Endocrinology Sep 2003 - 3799-810 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

0013-7227

10.1210/en.2003-0374 doi


Animals
Blood Glucose
Body Weight--physiology
Cattle
Dwarfism, Pituitary--blood
Eating--physiology
Female
Gene Deletion
Genotype
Growth Hormone--antagonists & inhibitors
Insulin--blood
Insulin-Like Growth Factor Binding Proteins--blood
Insulin-Like Growth Factor I--metabolism
Longevity--physiology
Male
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Mice, Knockout
Organ Size--physiology
Receptors, Somatotropin--genetics