CYP2C8 and CYP3A4 are the principal enzymes involved in the human in vitro biotransformation of the insulin secretagogue repaglinide.

Bidstrup, Tanja Busk

CYP2C8 and CYP3A4 are the principal enzymes involved in the human in vitro biotransformation of the insulin secretagogue repaglinide. [electronic resource] - British journal of clinical pharmacology Sep 2003 - 305-14 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0306-5251

10.1046/j.0306-5251.2003.01862.x doi


Antibodies, Monoclonal
Aryl Hydrocarbon Hydroxylases--antagonists & inhibitors
Biotransformation
Carbamates--metabolism
Chromatography, High Pressure Liquid
Cytochrome P-450 CYP2C8
Cytochrome P-450 CYP3A
Cytochrome P-450 Enzyme Inhibitors
Cytochrome P-450 Enzyme System--physiology
Drug Interactions
Humans
Hypoglycemic Agents--metabolism
Microsomes, Liver--enzymology
Piperidines--metabolism