Src mediates prolactin-dependent proliferation of T47D and MCF7 cells via the activation of focal adhesion kinase/Erk1/2 and phosphatidylinositol 3-kinase pathways.

Acosta, Juan J

Src mediates prolactin-dependent proliferation of T47D and MCF7 cells via the activation of focal adhesion kinase/Erk1/2 and phosphatidylinositol 3-kinase pathways. [electronic resource] - Molecular endocrinology (Baltimore, Md.) Nov 2003 - 2268-82 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0888-8809

10.1210/me.2002-0422 doi


Animals
Cell Division--drug effects
Cell Line, Tumor
Cyclin D1--metabolism
Enzyme Activation--drug effects
Focal Adhesion Kinase 1
Focal Adhesion Protein-Tyrosine Kinases
Humans
Mitogen-Activated Protein Kinases--antagonists & inhibitors
Phosphatidylinositol 3-Kinases--metabolism
Phosphoinositide-3 Kinase Inhibitors
Phosphotyrosine--metabolism
Prolactin--pharmacology
Protein-Tyrosine Kinases--metabolism
Proto-Oncogene Proteins pp60(c-src)--antagonists & inhibitors
Sheep
Signal Transduction--drug effects