A potent, selective inhibitor of matrix metalloproteinase-3 for the topical treatment of chronic dermal ulcers.

Fray, M Jonathan

A potent, selective inhibitor of matrix metalloproteinase-3 for the topical treatment of chronic dermal ulcers. [electronic resource] - Journal of medicinal chemistry Jul 2003 - 3514-25 p. digital

Publication Type: Journal Article

0022-2623

10.1021/jm0308038 doi


Administration, Cutaneous
Animals
Caproates--chemical synthesis
Cell Movement--drug effects
Cells, Cultured
Chronic Disease
Fibronectins--chemistry
Gelatin--chemistry
Humans
Keratinocytes--drug effects
Male
Matrix Metalloproteinase 3--chemistry
Matrix Metalloproteinase Inhibitors
Polycyclic Compounds
Protease Inhibitors--chemical synthesis
Rabbits
Skin--drug effects
Skin Diseases--drug therapy
Stereoisomerism
Structure-Activity Relationship
Ulcer--drug therapy
Valine--analogs & derivatives