Selective inhibitors of the osteoblast proteasome stimulate bone formation in vivo and in vitro.

Garrett, I R

Selective inhibitors of the osteoblast proteasome stimulate bone formation in vivo and in vitro. [electronic resource] - The Journal of clinical investigation Jun 2003 - 1771-82 p. digital

Publication Type: Journal Article

0021-9738

10.1172/JCI16198 doi


Animals
Blotting, Northern
Blotting, Western
Bone Development
Bone Morphogenetic Protein 2
Bone Morphogenetic Protein 4
Bone Morphogenetic Proteins--metabolism
Bone and Bones--metabolism
Carrier Proteins
Cell Division
Cell Line
Cysteine Endopeptidases--metabolism
DNA--metabolism
Dose-Response Relationship, Drug
Enzyme-Linked Immunosorbent Assay
Genetic Vectors
Humans
Luciferases--metabolism
Mice
Mice, Inbred ICR
Multienzyme Complexes--antagonists & inhibitors
Organ Culture Techniques
Osteoblasts--metabolism
Promoter Regions, Genetic
Proteasome Endopeptidase Complex
Proteins--metabolism
RNA, Messenger--metabolism
Skull--metabolism
Transcription, Genetic
Transfection
Transforming Growth Factor beta