High glucose augments the angiotensin II-induced activation of JAK2 in vascular smooth muscle cells via the polyol pathway.

Shaw, Sean

High glucose augments the angiotensin II-induced activation of JAK2 in vascular smooth muscle cells via the polyol pathway. [electronic resource] - The Journal of biological chemistry Aug 2003 - 30634-41 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

0021-9258

10.1074/jbc.M305008200 doi


Acetophenones--pharmacology
Aldehyde Reductase--antagonists & inhibitors
Angiotensin II--pharmacology
Animals
Antibodies--pharmacology
Aorta--cytology
Benzothiazoles
Cells, Cultured
Drug Synergism
Electroporation
Enzyme Inhibitors--pharmacology
Glucose--pharmacology
Intracellular Signaling Peptides and Proteins
Janus Kinase 2
Muscle, Smooth, Vascular--cytology
NADPH Oxidases--immunology
Oligonucleotides, Antisense--pharmacology
Phosphoproteins--immunology
Phosphorylation
Phthalazines--pharmacology
Polymers--metabolism
Protein Kinase C--metabolism
Protein Kinase C beta
Protein Tyrosine Phosphatase, Non-Receptor Type 11
Protein Tyrosine Phosphatase, Non-Receptor Type 6
Protein Tyrosine Phosphatases--metabolism
Protein-Tyrosine Kinases--metabolism
Proto-Oncogene Proteins
Rats
Reactive Oxygen Species--metabolism
Thiazoles--pharmacology
Tyrosine--metabolism
Vasoconstrictor Agents--pharmacology