Synthesis and structure-activity relationship of alpha-sulfonylhydroxamic acids as novel, orally active matrix metalloproteinase inhibitors for the treatment of osteoarthritis.

Aranapakam, Venkatesan

Synthesis and structure-activity relationship of alpha-sulfonylhydroxamic acids as novel, orally active matrix metalloproteinase inhibitors for the treatment of osteoarthritis. [electronic resource] - Journal of medicinal chemistry Jun 2003 - 2361-75 p. digital

Publication Type: Journal Article

0022-2623

10.1021/jm0205548 doi


ADAM Proteins
ADAM17 Protein
Administration, Oral
Animals
Biological Assay
Cartilage--drug effects
Cattle
Dialysis
Hydroxamic Acids--chemical synthesis
Matrix Metalloproteinase 13
Matrix Metalloproteinase Inhibitors
Metalloendopeptidases--antagonists & inhibitors
Mice
Osteoarthritis--drug therapy
Protease Inhibitors--chemical synthesis
Rats
Structure-Activity Relationship
Sulfones--chemical synthesis